Peripheral neuropathy - Symptoms and causes (Mayo Clinic)

Tier 1: Established: peer-reviewed research or government health authority
Publisher: Mayo Clinic · Published: August 28, 2026 · Accessed: August 28, 2026

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• Peripheral neuropathy happens when the peripheral nerves (outside the brain and spinal cord) are damaged; it often causes weakness, numbness and pain, usually in the hands and feet.
• People with peripheral neuropathy usually describe the pain as stabbing, burning or tingling.
• One of the most common causes of neuropathy is diabetes; neuropathy can also result from traumatic injuries, infections, metabolic conditions, autoimmune diseases, inherited causes and exposure to toxins.
• Seek medical care right away if you notice tingling, weakness or pain in your hands or feet; early diagnosis and treatment give the best chance of managing symptoms and preventing further nerve damage.
• Symptoms can include gradual onset of numbness, prickling or tingling in the feet or hands spreading upward; sharp, jabbing, throbbing or burning pain; extreme sensitivity to touch; and pain in the feet under a blanket.