Endometrial cancer - Diagnosis and treatment (Mayo Clinic)

Tier 1: Established: peer-reviewed research or government health authority
Publisher: Mayo Clinic · Published: September 4, 2026 · Accessed: September 4, 2026

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• Tests and procedures used to diagnose endometrial cancer include a pelvic exam, imaging tests, hysteroscopy, removing a sample of tissue for testing (biopsy), and surgery to remove tissue for testing.
• In an endometrial biopsy, a sample of tissue is removed from the lining of the uterus. Endometrial biopsy often is done in a health care professional's office.
• A transvaginal ultrasound uses a wandlike device inserted into the vagina to create a video image of the uterus; the image shows the thickness and texture of the endometrium.
• If enough tissue can't be obtained during a biopsy or if the biopsy results are unclear, you'll likely need to undergo a procedure called dilation and curettage (D&C), during which tissue is scraped from the lining of the uterus and examined for cancer cells.