Mental Health (The Menopause Society)

Tier 1: Established: peer-reviewed research or government health authority
Publisher: The Menopause Society · Published: August 7, 2026 · Accessed: August 7, 2026

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Claims this source supports

• Estrogen receptors are widely distributed in the brain, including in the regions involved in mood regulation; mood symptoms may be related to big swings in estrogen levels during perimenopause, but the precise mechanism isn't known.
• Women appear to be particularly vulnerable to depression during the perimenopause years and in the years immediately after menopause.
• The presence of stressful life circumstances or events may play a role in mood, as can the presence and severity of menopause symptoms such as hot flashes and sleep changes.