Pharmacy Times - Estrogen Impacts the Effects of Psilocybin for Women (2023)

Tier 3: Supporting source (media, company, or community), never used alone for health claims
Publisher: Pharmacy Times · Published: August 11, 2023 · Accessed: August 14, 2026

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Claims this source supports

• Estrogen can affect binding at serotonin receptor sites, which means psilocybin (acting through psilocin at those receptors) can impact women's bodies differently than men's - including variation across the menstrual cycle.
• The menstrual cycle runs along the hypothalamic-pituitary-gonadal (HPG) axis, which overlaps with the stress-response HPA axis; Chesak notes the two axes impact each other, so where a woman is in her cycle may matter for psychedelic effects, though more research is needed.
• There are case studies and anecdotal reports (not clinical trials) of psilocybin affecting menstrual cycles, including re-regulation of irregular cycles; the author is explicit that controlled research is lacking.